Sh2-279 (alternatively designated S279 or Sharpless 279) is an HII region and bright nebulae that includes a reflection nebula located in the constellation Orion. It is the northernmost part of the asterism known as Orion's Sword, lying 0.6° north of the Orion Nebula. The reflection nebula embedded in Sh2-279 is popularly known as the Running Man Nebula.